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Glossary - C

PART/CELL NAME

ABBREVIATION

SYNONYMS (S)
ANTONYMS (A)

LINEAGE DESCRIPTION

C

C blastomere (S)
C founder cell (S)

P0.ppa

An embryonic founder cell which is born dorsally and whose daughter cells give rise to dorsal hypodermis, some somatic muscle cells and several neurons.

In earlier publications,"C" may also refer to the postembryonic blast C cell (C ectoblast) which was later renamed "Y".

C blastomere   C founder cell
"c" neuron AWC cell (S)  

Amphid wing "c" cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath


See AW (Amphid wing) cell

"C" neuron CEP cell (S)   See CEP cell
CA cell

CA1
CA2
CA3
CA4
CA5
CA6
CA7
CA8
CA9

P3.aapa
P4.aapa
P5.aapa
P6.aapa
P7.aapa
P8.aapa
P9.aapa
P10.aapa
P11.aapa

Male specific cell
Male specific cell
Male specific cell
Male specific neuron, innervates dorsal muscles
Male specific neuron, innervates dorsal muscles
Male specific neuron, innervates dorsal muscles
Male specific neuron, innervates dorsal muscles
Male specific cells in VC, neuron-like, but lack synapses
Male specific cells in VC, neuron-like, but lack synapses

Caenorhabditis brenneri

Previously unnamed strain PB2801 was renamed in honor of Syndey Brenner. While closely related to C. elegans and C. briggsae, and having similar biological characteristics, adults are either male or female, not hermaphrodites. Sequencing of the genome is ongoing.


See Phylogeny

Caenorhabditis briggsae

A commonly studied species of nematode whose anatomical features are extremely similar to Caenorhabditis elegans, and whose genetic sequences are being compared in exacting detail against the genome of C. elegans. C. briggsae and C. elegans cannot interbreed to create fertile progeny, but are otherwise extremely similar in behavior and ecology; they are likely to be very close relatives evolutionarily (Nigon and Dougherty, 1949; Baird et al., 1992).


See Phylogeny

Caenorhabditis elegans A species of nematode, or roundworm, that has been adopted as a model organism for the study of genetics, cell biology, development, and neuroscience. Two different wild strains, Bristol and Bergerac, were initially adopted by Nigon and Dougherty (1949) and by Brenner (1974) as the basis for scientific studies, although additional wild-caught strains have since been collected around the world for comparisons of genetic diversity. The sequence of the entire genome was published in 1998 (with the last gaps finished in 2002) making C. elegans the first multi-cellular eukarote in which every base is known (C. elegans Sequencing Consortium, 1998).
Caenorhabditis japonica A species of rhabditid nematode closely related evolutionarily to Caenorhabditis elegans and Caenorhabditis briggsae. Like C. remanei, C. japonica does not form hermaphrodites, but utilizes a male/female sexual mating system. Additionally, it appears that unlike C. elegans, C. japonica may enter the dauer stage regardless of food and environmental conditions. This species is usually found in close association with stink bugs. Full sequencing of the genome is currently in the initial stages.
Caenorhabditis remanei A species of rhabditid nematode closely related evolutionarily to Caenorhabditis elegans and Caenorhabditis briggsae. C. remanei does not form hermaphrodites, but utilizes a male/female sexual mating system. For research purposes, most widely used strains of C. remanei are EM464 and SB146. Note that the strain CB5161, which was called C. remanei for some time, is actually a different species (and now believed to be C. brenneri). Full sequencing of the genome is currently in the initial stages.
CAN cell

CANL
CANR

ABalapaaapa
ABalappappa
A pair of neurons with processes that run along excretory canals and within canal associated nerves. Make no synapses, but essential for survival.
Canal associated nerve   A pair of longitudinal nerve tracts that run alongside the excretory canals on the right and left side of the animal. Processes from CAN, BDU, PVD and ALA form this nerve.
Canaliculus/Canaliculi (/plu)   A series of thin membranous collecting channels, closed at their distal ends, which feed into lumen of each excretory canal. The canaliculi can differ in shape depending on the status of the animal, perhaps reflecting changes in osmolarity or secretory activity. Thus the canaliculi can be 1) smooth, narrow and sinuous, or 2) undulating in diameter to form a series of beads on a chain, or 3) disconnected to form a series of larger spherical vesicles.
Canonical allele   The original isolate of a mutation whose properties define the basis for recognizing this strain as a separate class of mutant. (e.g. let-7(mn122) and unc-35(e259)). The severity of the phenotype of this allele is used as a measure against which the phenotypes of later alleles are compared.
Cap

Cap cell (S)
Socket cell (S)

 

1) Older name for socket cell.

2) Can also refer to a large piece of shed cuticle that had originally covered the head. From the cap’s dimensions, it has been suggested that secretions from the excretory system might provide a molting enzyme that works to weaken this piece of cuticle near the excretory pore at the back of the head in some species (Chitwood and Chitwood, 1951; Bird and Bird, 1991). In C. elegans, laser ablation experiments to remove the excretory system have not inhibited the molting process (Singh and Sulston, 1978).


See Socket cell

Cardia   See Pharyngeal-intestinal valve

Cauda/Caudal

 

Tail/of a tail, relating to a tail. Located at or directed towards the posterior part of the body.

Caudal alae  

The lateral specialization of the cuticle in the male tail, more commonly known as the fan.


See Fan

Caudal glands   These are found in "Adenophorea" only. There are 3 caudal glands with a common or separate openings at the tip of the tail. The secretion is used to attach the worm to the substrate.
Caudal papillae Male tail rays (S)   See Ray
Caudalids (archaic) Lumbar comissures (S)   The nerve connections between the lumbar ganglia and the pre-anal ganglion, which must circumvent the ventral opening of the anus.
Caveola / Caveolae (/plu)  

Vesicular organelles which are a specialized feature of some plasma membranes. They could be the basis of endocytosis or other forms of membrane-trafficking in some nematode cell types. Caveolae are notably smaller and less electron dense than coated vesicles 50-100 nm for caveolae, 200-300 nm diameter for coated vesicles, according to Razani and Lisanti (2001). Caveolin proteins are principal components of these organelles.

A caveolin-1 mutant in C. elegans blocks cell cycle progression (Scheel et al., 1999).


See Coated vesicle

ccDL herm
ccDR herm
M.dlpa
M.drpa
A pair of postembryonic coelomocytes in hermaphrodite.
ccD male M.dlpappp Single postembryonic coelomocyte in male.
ccAL
ccAR
ccPL
ccPR
MSapapaaa
MSppapaaa
MSapapaap
MSppapaap
Embryonic coelomocytes
Cecum/Ceca (/plu)  

An outpocketing (diverticulum) or blind ending of the lumen of the intestine, usually forming a side branch of the lumen proper. In C. elegans, the anterior intestinal lumen between the first four cells is quite large in volume, but no distinctive side branches form there.

Ceca are common in some other nematode species, especially at the anterior limit, and may form along the length of the intestine of some C. elegans mutants.

Ced  

CEll Death abnormality phenotype or mutation.


See Cell death

Cell body Soma (S)   The largest portion of a cell, generally surrounding the nucleus and containing abundant cytoplasm and organelles.
Cell death  

There are a number of distinct mechanisms by which individual cells within the organism can die, generally without direct death of the whole animal. In C. elegans, many cells die via apoptosis, or programmed cell death, soon after their birth (Conradt and Xue, 2005). In a variety of disease mechanisms, in old age, in some mutant phenotypes, and after toxic treatments, various cells may be induced to die by alternate mechanisms, which include necrosis (Syntichaki and Tavernarakis, 2002). These pathways are distinct, but share some components and cellular machinery. The morphological features of these various modes of death are in some ways distinctive, but dying cells can often show mixed characters. The corpses of dead cells rarely linger, but are quickly engulfed and phagocytosed by neighboring cells.


See Apoptosis
See Necrosis
See Autophagy
See Programmed cell death
See Engulfment

Cell fusion  

A common feature in C. elegans tissues, in which the lateral borders of two or more cells become tightly fused and then open to form a patent channel between the cells (Podbilewicz and White, 1994; Podbilelwicz, 2006). In some cases, the point of fusion remains quite small, and fragments of the former cell border can be retained, such that the cells seem virtually separate (as in pharyngeal muscle cell pairs). In other cases, all vestiges of the former border are removed, cell nuclei migrate across from one zone to the next, and the combined syncytial structure shows little resemblance to the original chain of cells (as in the hyp7 syncytium). In the germline, all young germ cells are fused to a common rachis and may share intracellular components with the rachis, yet these cells mature independently and eventually separate from the rachis (reversing

In C. elegans, syncytial cells include some of the hypodermal cells, excretory gland cell, vulva epithelium, uterus epithelium, pharyngeal muscles, pharyngeal epithelial marginal cell, pharyngeal g1 gland cell, ant and post arcade, tail spike cells and seam cells.


See Rachis
See Syncytium

Cell intercalation  

A developmental process that results in the rearrangement of several C. elegans tissues in which cells migrate for short distances from their place of birth to surround a developing epithelial structure, as in the intestine and vulva, or to form a discrete chain of cells such as the ventral nerve cord and embryonic hypodermis.

Intercalation can be used to describe the positions of excess cells (or structures) that come to lie within a row of other cells due to changes in cell fate due to mutation or developmental anomalies.

Cell invasion   See Invasion
Cell lineage   The pattern of cell divisions and cell fates produced by an ancestral blast cell. This series of cell divisions is highly stereotyped in C. elegans (See Lineage tree), so that most dividing cells have reproducible axes of their division planes (e.g. dorsal/ventral, anterior/posterior, etc), and reproducible timing in the divisions and asymmetries in the relative size of the two daughter cells. Segregation of nuclear determinants within the two daughters is also reproducible resulting in consistent cell fates among the daughters from animal to animal. Cell lineages are often depicted graphically as decision trees.
Cell migration  

Some cells are born at some distance from their terminal locations as mature cells, and must crawl in amoeboid fashion within the body cavity to reach their eventual destination. They follow molecular signals expressed by cells along the route of their migration or by cells within their target tissue.

During gastrulation, many young cells shift positions within the expanding embryo to form an internal layer of cells. The distal tip cells differentiate and then begin to crawl within the body cavity to guide outgrowth of the gonad. The hypodermal cells of the male tail migrate to lead the retraction (migration) of other cell types from the extreme tail tip prior to morphogenesis of the posterior fan and rays.

One differentiated cell type, the gonad sheath cell (1st pair only) in the mature adult gonad appears to crawl continuously by filopodial extension to try to cover the exposed surface of the dividing germline. Some sensory neurons which are born at the surface of the body, later migrate inward and towards the central ganglia, leaving behind a sensory dendrite attached to the bodywall. Many larval cells make shorter migrations in tissues as they reposition themselves to form epithelial layers, including the developing intestine.

Cellular sheath   See Gonad sheath
Cellularization  

Process by which maturing germ cells, which are initially connected via the rachis within the distal gonad arm, break free from the rachis to continue the final stages of development, either as individual spermatocytes or oocytes, or to undergo programmed cell death.


See Cell fusion
See Nurse cells
See Rachis

CEM cell

CEMDL
CEMDR
CEMVL
CEMVR

Cephalic companion cell (S)

ABplaaaaaap
ABarpapaaap
ABplpaapapp
ABprpaapapp

A sensory neuron cell type found in the head of males but not hermaphrodites (these cells die in the hermaphrodite embryo). Each CEM shares the same sheath cell as the CEP neuron in the four dorsal and ventral lips, and forms a sense ending which opens separately to the exterior through the cuticle (See Cephalic Sensilla). They may mediate male chemotaxis towards hermaphrodites.

Central cells  

See Wishbone cells

Central cylinder

 

See Apical ring

Central element  

A specific portion of the chromosomal pair during synapsis that forms part of the synaptonemal complex and runs between the lateral elements. Ladder-like in structure, it has two longitudinal components and regularly spaced transverse components that bridge the longitudinal components and may be subdivided into 3-4 layers (Schmekel and Daneholt, 1995).

See Axial element
See Lateral element
See Synaptonemal complex

Centration

 

A coordinated movement during prophase of the two centrosomes and the two pronuclei towards the center of the one cell embryo (Gönczy and Rose, 2005)

Centriole  

A small cylindrical structure, usually found in pairs, that are found at each pole of the mitotic spindle in animal cells and some other eucaryotes. Centrioles lie perpendicular to one another to form the centrosome and organize the mitotic spindle for cell division. While in most animals, centrioles are composed of nine triplet microtubules, in C. elegans the centriole has a nine singlet conformation (for more detail see Oegema and Hyman, 2006).

Centrioles are also found distally in the dendrites of some sensory neurons, at the basal pole of the cilium. Presumably the centriole organizes the microtubules which make up the distal cilium, and perhaps the contents of the striated rootlet, where present.


See Centrosome

Centrosome  

This structure acts as the primary microtubule organizing center (MTOC), and is important both for creation of the mitotic spindle during cell division, and for creation of the cytoplasmic network of microtubules during cytokinesis and during G1 and G2 phases. The centrosome contains two centrioles, plus the intermediate filament protein, IFA, and is generally surrounded by a halo of other fibrous materials including the ZYG-9 protein (Leung et al., 1999). Shortly after fertilization of the early embryo, the centrosome becomes anchored to the plasma membrane asymmetrically near the point of entry of the sperm into the egg; this anchoring point helps to establish the initial polarity of the embryo. Later in cell division, just after duplication of the centrosomes, the two daughter centrosomes show specific movements within the cytoplasm to organize two independent mitotic spindles, including the “rotation” of one centrosome versus its sister, and the “centering” of each centrosome within two different domains to establish separate regions with independently organized axes of polarity.


See Centriole

CEP cell CEPDL
CEPDR
CEPVL
CEPVR
ABplaaaaappa
ABarpapaappa
ABplpaappppa
ABprpaappppa

All four are dopaminergic neurons of cephalic sensilla.


See Cephalic sensilla section

Cephalic nerve cord   See Mechanosensory nerve
Cephalic sensilla  

Refers specifically to the sensory specializations of the CEP and CEM neurons and socket and sheath cells. In some nematode species these sensilla lie on the head (hence “cephalic”) rather than on the lips (Coomans, 1979), but in C. elegans the cephalic sensilla lie close to the outer labial (OL) sensilla on the lips proper (See Cephalic sensilla section).


See CEP cell
See CEM cell

Cephalic sheath cell CEPshDL
CEPshDR
CEPshVL
CEPshVR
ABarpaaaapp
ABarpaaapap
ABplpaaapap
ABprpaaapap
Refers to the sheath cells of the cephalic sensilla of the nose. Includes CEPshDL/R, CEPshVL/R. Their sheet-like processes envelop neuropil of ring and part of ventral ganglion (See Cephalic sensilla section).
Cephalic socket cell CEPsoDL
CEPsoDR
CEPsoVL
CEPsoVR
ABalapapppp
ABalapppppp
ABalppaappp
ABalaapappp
Socket cells of the cephalic sensilla (See Cephalic sensilla section).
Cephalid  

A cuticular specialization found in some plant parasitic nematodes, appearing highly refractile, possibly due to thinning of the cuticle within one annulus, local tissue adhesion to the cuticle, or the local passage of a nerve commissure close to the annulus (McLaren, 1976).


See Hemizonid

CEPsh cell   See Cephalic sheath cell
CEPso cell   See Cephalic socket cell
Cervical papillae Anterior deirid (S)  

See Deirid

CFP  

Cyan fluorescent protein.


See GFP

Channel(s)   Narrow cuticle-lined tubes lying at the three corners of the pharyngeal lumen that are likely to remain open even when the rest of the lumen is closed during pharyngeal pumping. It has been proposed that these channels allow outward flow of fluid from the pharynx during pumping (Albertson and Thomson, 1976).
Cheilorhabdion   Specialized zone of cuticle lining the cheilostom, formed by the cells of hyp1, hyp2 and hyp3. The term refers to this zone as seen by the light microscope.
Cheilostom Lip cavity (S)  

The most anterior portion of the buccal capsule or stoma. It is the portion of the anterior digestive tract which is enclosed by the lips.


See Prostom
See Telostom

Chemical synapse  

Area of neuron to neuron communication where the "presynaptic" process releases the chemical contents (neurotransmitter or neuropeptide) of a small vesicle into the extracellular space to signal one or more nearby “postsynaptic” neuron processes. In C. elegans, the release zone within the presynaptic process typically shows a small collection of synaptic vesicles and an electron dense specialization attached to the cytoplasmic face of the plasma membrane. Unlike higher animals though, the postsynaptic processes rarely display any membrane density marking the collection of receptors. Chemical synapses may have one postsynaptic target (monadic), two targets (dyadic) or three targets (triadic).


See Electrical synapse
See Gap junction

Chemoattractant

Attractant (S)
Repellant (A)

  See Attractant
See Repellant
Chemorepellant

Repellant (S)
Attractant (A)

 

See Repellant
See Attractant

Chemosensation  

Detection of a chemical cue which elicits a response in the animal so that it can react to food, danger or the presence of other animals. The amphids, which contain 11 pairs of chemosensory neurons, are the primary chemosensory organs. See Bargmann, 2006 for more detail.


See Amphid sensilla section
See Chemotaxis

Chemosensory ending   A specialized, ciliated portion of a neuron’s dendrite which lies exposed to external chemical stimuli through a hole in the cuticle. Most chemosensory endings in C. elegans consist of a neuron and one or more accessory cells which form a pocket around the cilium to bathe the ending in a fluid-filled chamber.
Chemosensory nerve   A collection of neuronal processes (dendrites) which run from a discrete group of chemosensory endings (such as the amphid or phasmid) to their cell bodies and/or their neuropil. Most chemosensory neurons extend a single dendrite via a chemosensory nerve to their sensory ending, and a second process (axon) to the neuropil of a nearby ganglion or nerve ring.
Chemotaxis  

The guided behavior of an animal to approach or avoid the source of a chemical signal in the environment. In C. elegans, chemoreceptors in the lips sense these signals and the animal can be observed to wag its head from side to side, apparently to compare signal strengths and detect the direction of a chemical gradient, before moving its whole body up (positive chemotaxis) or down (negative chemotaxis) the gradient. The animal modulates its rate of turning to redirect itself up or down the gradient (Miller et al., 2005; Bargmann, 2006). Chemotaxis assays have been developed to study this behavior and the cells and genes that are involved in C. elegans.

Chemotropism   The growth of a portion of a cell towards or away from a chemical signal. In C. elegans this term has been used in relation to the guidance or repositioning of muscle arm extensions.
Chitinous layer  

The most prominent layer within the eggshell, lying between the inner “lipid layer” (the “inner” vitelline membrane), and the outer vitelline layer. Although the development of this layer is still unclear in C. elegans, the chitinous layer is perhaps secreted by the oocyte itself, just after fertilization.

According to Bird and Bird (1991), the eggshell is the only place in nematodes where chitin is known to be utilized. There are protein structures mixed into this layer in some nematode species as microfibrils or as radial pillars, but these have not been demonstrated in C. elegans.


See Eggshell
See Oolemma
See Zona pellucida

Chitinous shell   See Eggshell
Chord   See Cord
Chromatin   The network of chromosomal material found within the nucleus, made from DNA strands and associated histone proteins. Based upon its staining properties, it is divided into two components, euchromatin (lower staining) and heterochromatin (higher staining). Only the former is thought to be very active, as it is more loosely wound and open to transcriptional machinery. See Schaner and Kelly, 2005.
Chromomere   A region along the length of a chromosome where the material is more darkly staining due to local condensation of the genetic material. Chromosomal bands consists of local clustering of chromomeres.
Chromosome   A structure in the cell nucleus which contains the genetic material encoded as DNA and surrounded by histone proteins and other regulatory elements. In C. elegans the normal cell contains 5 pairs of “autosomes” and one or two X chromosomes.
Ciliary cap Nubbin (S)  

Dense material displayed in the cuticle in association with the tip of the sensory cilium as in the cephalic sensory cilia.

Ciliary necklace  

A distinctive arrangement of doublet microtubules that form a circular ring when viewed in cross-section, found within the basal bodies of many chemosensory cilia in C. elegans including the amphids (Perkins et al., 1986).

Ciliome  

A ciliary proteome database which includes cilia-associated proteins (Inglis et al., 2006).

Cilium / Cilia (/plu)  

Long, usually motile, whiplike or hairlike appendages that are attached to eukaryotic cells. Cilia contain an axoneme which is made of a pair of central microtubules surrounded by nine pairs of microtubules around the outside (9+2 arrangement). Although the cilia in nematodes are homologous to the cilia in other animals, they are not motile. To date, no nematode with motile cilia has been found. Cilia are retained in sensory organs in nematodes in which the specialized sensory ending of a neuron often features a bundle of microtubules extending distally from a basal body, most often very distant from the cell soma (For more detail see Inglis et al., 2007).

A wide variety of specializations are known among the cilia in C. elegans, including local branches, intracellular dense blobs or dark vesicles, striated rootlets that can extend proximal to the basal body, and local external attachments to the basal lamina, the cuticle or within a glial (structural) cell. They are presumed to be the site of sensory transduction by a specific modality for which the ciliary specializations are suited; e.g. chemo-, osmo-, thermo-, mechano-, photo-, etc. Signals transduced by the cilium are carried to the sensory cell soma by a dendrite and then along an axon to the cell’s synapses.

Circomyarian  

Describes a muscle cell in which the sarcomeres completely encircle the outer bound of the cell, with the cytoplasmic muscle belly confined to a central core of the cell. Only a few specialized muscles in nematodes may fit this condition.


See Meromyarian

Cistern / Cisternae   A thin clear space enclosed by a unit membrane, often occurring as parallel close fitting spaces. References to cisternae in earlier nematode literature most likely refer to rough ER in a cell soma, or less often to smooth ER or sarcoplasmic reticulum in distal cell processes. Some cells have distinct sets of cisternae, including the amphid sheath cells where they are named lamellae, and some of the ray neuron cell bodies of the male tail.
Clear phenotype clr  

A very distinctive phenotype in which the adult nematode is remarkably transparent when viewed by light microscopy due to a single gene mutation, clr-1 (Kokel et al., 1998). These animals also exhibit other morphological changes, including some bloating and a shorter body length.

clr-1 encodes a receptor tyrosine phosphatase which attenuates signaling by egl-15, a fibroblast growth factor receptor. It appears that these genes act in the hypodermis to regulate fluid homeostasis (Huang and Stern, 2004).

Cleidoic   Term is used to describe an impermeable eggshell, like that of C. elegans, where there is no exchange of water and fats, and resists physical deformation. Only gases seem to be permeant (Anya, 1976). Such eggs are environmentally isolated and the developing embryo cannot be fed by osmosis through its exterior.
Cloaca  

A structure in the adult male tail, equivalent to the proctodeum (rectum and anus) of the hermaphrodite, where the vas deferens and the intestine open out jointly into an enclosed sinus near the tail tip to discharge their contents. The cloaca refers to the cuticle-lined chamber where these tissues join, including the spicule pouch and ventral opening, but not to the cells themselves, which are all part of the proctodeum (Lints and Hall, 2005).


See Gubernaculum
See Proctodeum

Cloacal ganglia   A pair of neuronal ganglia in the adult male tail, lying on either side of the proctodeum, but not found in the hermaphrodite.
Clr Clear  

CLeaR phenotype or mutation.


See Clear phenotype

Clumping behavior   The tendency of a population of animals to collect closely together into larger piles or clumps. This behavior is often observed in normal animals on plates where the food is about to be exhausted, where they pile up at the edges of the lawn of bacteria.
Coated pit  

An intermediate stage of endocytosis, in which the plasma membrane indents when organized by a coat of clathrin on the cytoplasmic surface; the coated pit continues to indent and become more spherical until it breaks off to form a coated vesicle. They have been seen in neurons near synapses and at the base of sensory cilia and in coelomocytes (Hall, unpublished). Coated pits are larger in diameter than coated vesicles.


See Caveola / Caveolae
See Coated vesicle

Coated vesicle   A specialized small vesicle associated with endocytosis, often found at the plasma membrane, or associated with vesicular trafficking between membranous lamellae deeper inside a cell, such as at Golgi stacks or rough ER. The outer coat is made from primarily from clathrin protein.
Coelomic cavity  

Cavity formed between separate mesodermal layers which, in vertebrates, includes pleural, peritoneal and pericardial spaces. The mesodermal layer around the coelomic cavity is an epithelium proper with a basal lamina on the outside and very often cilia facing the lumen. There is no true coelomic cavity in the nematodes but a pseudocoelom.


See Pseudocoelom

Coelomocyte   A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans that can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, often lying pairwise together, and they display prominent cytoplasmic inclusions and vacuoles.
Coiler   A behavioral phenotype common to some classes of uncoordinated mutations, in which the animal commonly comes to rest in a tightly coiled posture, forming a spiral, and tending to remain stationary in this position rather than actively moving on the plate. In some classes of mutation, the animal may favor coiling specifically in one handedness, being either a “dorsal coiler” (with all dorsal muscles in contraction) or a “ventral coiler” (with all ventral muscles in contraction). Some mutations lead to coiling when the animal is reversing, but not during forward motion. The mutations seem to interfere preferentially with neuronal input to the bodywall muscles so as to block the normal pattern of alternating waves of contraction along the bodywall which would flex the animal in alternating dorsal and ventral contraction.
Cold sensitive   Referring to a temperature-sensitive mutation whose phenotype is exacerbated by low temperature (often 15 or 16oC), but becomes more normal at room temperature.
Collar  

In the spermatozoon, an electron dense cytoplasmic specialization surrounding an ER membrane through which the membrane converts to form smaller membranous vesicles on the cis face of the Golgi apparatus (Wolf et al., 1978). The two portions of membrane compartment separated by the collar have also been referred to as the head lobe (smaller) and body lobe (larger) (Achanzar and Ward, 1997). After fusion of the membranous organelle with the spermatozoon’s plasma membrane, the collar is thought to persist and to reinforce the fusion pore, keeping it open while fibrous contents from the MO are extruded to the outside surface of the spermatozoon.


See Membranous organelle

Colonizing  

1) A nematode's ability to invade and reproduce in a local habitat.

2) The ability of a bacteria, fungus or virus to invade the nematode and reproduce there.

Comma   A middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell.
Command interneuron Command neuron (S)  

Interneurons whose synaptic output represent a “final common pathway” to motor neurons. The synaptic activities of command interneurons lead directly to the control of locomotion. This group of interneurons include AVA, AVB, AVD, AVE and PVC.


See Interneuron

Commensal  

A lifestyle in which two species live together (and perhaps to feed together), at no harm to either organism and for the benefit of one (but not both) of the organisms. If both species derive obvious benefits, it is considered mutualism.  It has been suggested that C. vulgaris may have a commensal relationship with pillbugs in the wild, living under the shell of the pillbug and perhaps consuming bacteria there (Baird et al., 1994).


See Free living
See Mutualism
See Necromenic
See Parasite
See Phoretic

Commissure  

The passage of a neuron process or a bundle of neuron processes between two different nerve cords or between two bilateral ganglia. In higher animals a commissure always consists of many processes traveling in parallel to reach a shared destination. However, in C. elegans, a commissure can consist of a single neuron process. Such commissural axons in the nematode always travel in direct contact with a thin coating of the hypodermis, and most run circumferentially along the outer body wall.

Commissures in C. elegans are:
Amphid commissure:
bilateral
Deirid commissure: bilateral
Dorso-rectal commissure: bilateral
Lumbar commissure: bilateral, comprises the full route of axons from preanal ganglion (ventral side) to dorsal cord
Lumbar-preanal commissure: bilateral, a portion of the lumbar commissure comprising the ventral to lateral portion only
Motor neuron commissures: each runs either from left or right side, processes of D type motor neurons that travel from ventral cord to dorsal cord along the body


See Commissures section

Con CONstipated  

A defecation mutant phenotype where animals exhibit delayed or infrequent defecation cycles.


See Defecation motor program
See Constipated/ Constipation

Confocal microscopy

LSCM (S)
Laser scanning confocal microscopy (S)

 

This high resolution microscopy is used for imaging fluroescent signals in fixed specimens.

Connectivity diagram Wiring diagram (S)   The overall pattern by which a set of neurons interacts synaptically with each other.
Constipated/Constipation  

A reduction in the normal rate of defecation, leading to an abnormal buildup of digestion products inside the lumen of the hindgut.


See Defecation motor program

Contact termination Branch termination (S)  

A feature in which two neuron processes touch each other to form a gap junction and terminate at that point. Very common at the distal extreme of the nerve ring (most commonly between bilateral processes extending from neurons of the same class) and along the length of some motor nerves (between functional homologues such as VD's or DD's).

Contralateral Ipsilateral (A)  

Refers to a cell or cell extension which lies across the midline from a reference object.

Continuous junction Smooth septate junction (S)  

An intercellular junction found only in the spermatheca, in which the two plasma membranes are separated at a distance (the septa) but show no cytoplasmic density or specialization to mark the junction. Their presence is most easily noted by MH27 (AJM-1) antibody staining.

Alternately, this term has been used to characterize extensive adherens junctions, or “belt desmosomes”, that extend “continuously” over the entire apposition of two epithelial cells.


See Septate junction

Convulsion  

A mutant phenotype in which the animal suffers from local contractions or stretching of the bodywall muscles occurring synchronously over all four dorsal and ventral quadrants, so that the local portion of the body seems to lengthen or shorten (Williams et al., 2004).  Global changes in length operating on all bodywall muscles synchronously are often called the Rubberband phenotype.


See Rubberband phenotype

Copulatory apparatus Copulatory structures (S)   The specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm.
Copulatory bursa Bursa (S)   See Bursa
Copulatory plug Mating plug (S)  

Gelatinous material deposited into the opening of the vulva of the hermaphrodite by a male at the termination of mating behavior. The plug can produce a visible swelling that completely covers the vulval region. The plug may preserve for up to 24 hrs before egg laying forces it to be shed.

Some strains of C. elegans males secrete plug material, while other strains do not (Barker, 1994). Presence of the plug has been shown to interfere with successful mating by a second male, and thus protects the sperm from the first male (the “plugging male”) from competition from sperm from a second male.

The ability to produce a plug is ascribed to the function of a single gene, plg-1 (Hodgkin and Doniach, 1997). The plug material appears to be formed by coagulation of a secreted yellow liquid, which collects in seminal vesicle during mating, and is secreted at the end of mating, during which time the male continues to “linger” near the vulva, after the termination of sperm transfer (Barker, 1994). plg-1 probably encodes a coagulant, not the yellow liquid itself, since non-plugging males also exude the yellow liquid.

Copulatory spicule   See Spicule
Cord  

This term has multiple, overlapping uses. It can refer to:

1) The bundled nerves running along the longitudinal body axis, i.e. “nerve cords”

2) the hypodermal extensions lying along the sides (dorsal, ventral, left or right), i.e. “hypodermal cords”

3) the combination of nerve processes plus hypodermis along the longitudinal body axis


See Hypodermal ridge
See Nerve cord

Core Rachis (S)   The syncytial acellular portion of the germline in the adult male nematode linking the cell bodies of individual germ cells; it appears completely the same as the rachis of the hermaphrodite gonad (Wolf et al., 1978).
Corpse   This term can refer either to the dead remains of a whole animal at the end of life (as in extreme old age, or after deadly insult, or lethal mutation) or to the dead remains of a cell that has undergone apoptosis or necrosis, but which has not yet been consumed by engulfment by a neighboring cell.
Corpus   An extended anterior region of the pharynx, which is composed of two subdomains, the procorpus (long and thin) and the metacorpus (first bulb), lying just anterior to the isthmus and terminal bulb. The muscular corpus lies just posterior to the pharyngeal epithelium, and anterior to the isthmus.
Cortex  

The outermost region of the cytoplasm, directly underlying the plasma membrane of a cell. It is a site of concentration for specific molecular determinants governing cell development and the point of anchorage for cytoskeletal elements (Munro et al., 2004). The term is often used with regard to the developing blastomere. Other cell types with distinctive specializations of their cortex include the intestine, the excretory canal, and the uterus (Gobel et al., 2004).


See Glycocalyx
See Lumen

Cortical contraction   Occurs in the developing fertilized oocyte prior to first cleavage. These contractions take place in a polarized fashion relative to the A/P axis of the embryo.
Cortical layer

Outer layer of cuticle (S)
Epicuticle (S)
Cortical Zone (S)

 

The outermost layer of the adult cuticle is called the cortical layer, and appears more densely staining both by light microscopy and by TEM observation. By some accounts the cortical layer can be subdivided further to identify an external cortical layer that is the darkest part, an internal cortical layer that is similar to the matrix layer, and a medial layer.


See Basal layer
See Fiber layers
See Fibril layer
See Matrix layer
See Epicuticle

Cortical rearrangement   Refers to changes in anatomical organization in the late stages of primary oocyte maturation just prior to fertilization, as viewed by light microscopy.
Cortical ruffling   Periodic indentations, or creases, of the first embryonic cell near the time of pseudocleavage that move laterally along the surfaces of the dividing fertilized oocyte, as viewed by light microscopy (Hird and White, 1993).
CP cell CP0
CP1
CP2
CP3
CP4
CP5
CP6
CP7
CP8
CP9
P2.aap
P3.aapp
P4.aapp
P5.aapp
P6.aapp
P7.aapp
P8.aapp
P9.aapp
P10.aapp
P11.aapp

Male specific cells in ventral cord
Male specific cells in ventral cord
Male specific cells in ventral cord
Male specific cells in ventral cord
Male specific motor neurons in ventral cord
Male specific motor neurons in ventral cord
Male specific motor neurons in ventral cord
Male specific motor neurons in ventral cord
Male specific interneurons project into preanal ganglion
Male specific interneurons project into preanal ganglion

Cpa   Term defines CytoPlasmic Appearance alteration mutant or phenotype in early embryo.
Crawling Gliding (S)
Creeping (S)
 

The typical undulating locomotory behavior displayed by most nematodes, including C. elegans when moving on a solid or semi-solid substrate (Crofton, 1971; Nicholas, 1975). C. elegans tends to crawl forward more often and more skillfully than backwards, except for adult males, which spend more time moving backwards.


See Swimming

Cristae  

The internal compartments formed by the inner membrane of a mitochondrion. The foldings of the membrane create a large surface area where the reactions for cellular respiration to take place.


See Mitochondrion

Cross bridge   May refer to the cell body and lateral branches of the excretory canal process that connects the left side canal and right side canal into an “H” shape. The cross bridge also is the site of the secretory membrane at which the canal cell dumps its contents into the excretory duct and pore.
Cross-over Decussation (S)   The crossing of an axon across the midline is sometimes referred to as "crossing-over" although the usual term is decussation.
Cross progeny   Progeny that derive from a mating event between male and hermaphrodite parents and not from self-fertilization within the hermaphrodite, which are termed self-progeny.
Crossing  

The deliberate production of cross-progeny by the mating of males and hermaphrodites.


See Backcross
See Outcross

Crumpled spicules  

A common deformity in the development of the spicules of the male tail as a result of certain mutations. This deformity generally causes male sterility. Whereas normal spicules are created as long straight rigid structures, supported by a keratinized outer cuticle, various mutations lead them to become malformed where they are shorter, bent or too pliable to function in mating behavior.


See Spicule

Cryptobiosis  

The ability to survive for long periods of time in a metabolically inactive state, whether due to low oxygen, low temperature (including freezing), dessication or even high temperature, among others.

This is different from diapause, but it would seem that larval stage animals are much better suited to survive cryptobiotic conditions than other stages or dauer animals. Similarly, in the laboratory, most mutant strains of C. elegans are best stored for long intervals (years) under liquid nitrogen as freshly starved L1-L2 larvae (Stiernagle, 2006). Some nematode species are much better suited to long term cryptobiotic survival than C. elegans (Nicholas, 1975).

Crystalloid   A category of free-floating cytoplasts found in the pseudocoelom of some nematodes (not known in C. elegans as yet) that accumulate high amounts of metal sulfides and some protein and carbohydrate into a granular objects.
Curl Curling (S)  

A distinctive posture of the male tail often seen in animals suspended in liquid medium, involving a deep bending on the ventral side. Adult males exposed to high serotonin levels exogenouosly often will curl and sometimes become frozen in this position (Loer and Kenyon, 1993).

Cuticle  

A rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells. It covers the outer body, the major openings into the body cavity (mouth, excretory pore, rectum) and two large sensory bristles, the male spicules. The cuticle of the spicules, the hook, and of some portions of the spicule channels is especially rigid and is probably sclerotized. Similar sclerotic features are occasionally noted in the ventral surface of the male tail fan, and are also seen at the three apices of the buccal cuticle, reinforcing the shape of the cuticle channels there.

The adult cuticle is comprised of many distinct layers, not all of which may be evident in any one cross-section by electron microscopy. Larval and dauer cuticles may look substantially different. The dauer cuticle is relatively much thicker than other stages (Kramer, 1997), as is the cuticle of very old adults (Herndon et al., 2002). However, neither condition seems to involve the creation of extra layers, but just the thickening of certain sublayers.

The cuticle of the buccal cavity and pharynx is qualitatively different from the body cuticle, lacking layers and forming a series of complex specializations, including the flaps, sieve and grinder. It is virtually separate from the body cuticle except for tenuous connections through the “bridging cuticle” (Hall, unpublished).

For more detail see Page and Johnstone, 2007 and WormAtlasHermaphrodite Cuticle and Dauer Cuticle sections.

See Basal layer
See Boundary zone
See Channel
See Cortical layer
See Fibril layer
See Molt
See Matrix layer

Cuticle collagens   Those collagen proteins that are expressed in the nematode cuticle at some time during the animal’s development or adult life stages. Genes encoding collagen proteins are among the larger gene families within the C. elegans genome. Some collagens are not expressed in cuticle, but instead help to form the basal laminae of various tissues (for more detail see Page and Johnstone, 2007).
Cuticle flaps   Three flaps extend inward from the lining of the buccal cuticle to restrict flow at the rear of the buccal cavity (Wright and Thomson, 1981). These flaps extend from the pharyngeal muscle cells m1 and m2. They are made of specialized cuticle and appear very electron dense in thin section, suggesting a sclerotic hardening to stiffen the flaps and the entryway to the true pharynx.
Cuticle furrows  

Shallow circumferentially-oriented indentations in the cuticle. The ridges between furrows are the annuli.


See Annuli

Cuticular nubbin CN   See Nubbin
Cyk Cytokinesis abnormal (S)   CYtoKinesis defect. Term defines abnormality in the division of a cell into two daughter cells
following mitosis.
Cytoneme   Thin tapered processes extended by somatic sheath cell #1 over the surface of the unsheathed gonad, near the transition zone (Hall et al., 1999; Hubbard and Greenstein, 2000).
Cytoplast Minicell (S)  

A non-viable cell fragment which has broken off from a parent cell, or also it can be a residual fragment of a dead or dying cell. Cytoplasts most often contain no nuclear material, and thus cannot reproduce or maintain themselves (Sulston and Horvitz, 1981). Other categories of cytoplasts may exist as exudates or waste products which assemble spontaneously outside of any cell, such as crystalloids in some species.


See Bleb
See Brush
See Crystalloid

Cytosome  

Archaic term for an organelle lying within a cell’s cytoplasm which might be either an endosome (membrane-bound) or a free granule, possibly comprised of yolk or lipid (Popham and Webster, 1979).




This section should be cited as: Herndon, L.A., Altun, Z.F. and Hall, D.H. 2009. Glossary C. In WormAtlas.  doi:10.3908/wormatlas.6.3
Edited for the web by Laura A. Herndon. Last revision: October 11, 2013.

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