Receptor expression:
- GLR-1; glutamate receptor subunit
- GLR-2; glutamate receptor subunit
- NMR-1; glutamate receptor subunit
- NMR-2; glutamate receptor subunit
- DEG-3; alpha subunit of a nicotinic acetylcholine receptor
(Brockie et al., 2001; Maricq et al., 1995; Treinin and Chalfie, 1995)
Function: Anterior guidepost neuron
- AVG pioneers the right tract of the ventral nerve cord. It expresses UNC-6 at 3-fold embryo stage to provide a continuous UNC-6 (netrin)-labeled pathway restricted to the right tract of the nerve cord.The unilateral UNC-6 cue from AVG guides various paired axons growing from the nerve ring and lumbar ganglia to make rightward decussations as they enter the ventral nerve cord. href="http://www.wormbase.org/db/gene/gene?name=WBGene00006746;class=Gene" target="_blank">UNC-6 also promotes bundling of axons within the cord itself. If the parent of AVG is ablated in wild-type embryos, interneurons and ventral cord motor neurons form several small fascicles rather than one tight bundle of right side tract and occasionally the right side axons shift to the left side
(Antebi et al., 1997; Wadsworth et al., 1996; Wadsworth and Hedgecock, 1986; Durbin 1987).
- Regulates sex-specific tail mechanosensation and vulva location behavior in males (Oren-Suissa et al., 2016; Setty et al., 2022).
Reporters:
- At CGC:
- Other: ZM9592 hpIs670 [pnmr-1::GFP ZF; pglr-5::ZIF-1::SL2::wCherry; lin-15(+)] (Taylor et al., 2021)
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