Type: Interneuron, (sublateral) motor neuron
In MoW: SIB
Male Wiring Project: SIBDL, SIBDR, SIBVL, SIBVR
In Wormbase: SIB, SIBDL, SIBDR, SIBVL, SIBVR
Lineage: AB plppaaaaa, AB prppaaaaa,
AB plpapaapp, AB prpapaapp
Location:
SIBV are in the ventral ganglion, while SIBD are in the lateral ganglia of the head
Description: SIB neurons extend their processes anteriorly into the nerve ring. These processes then exit the nerve ring posteriorly within the ventral or dorsal sublateral cords
Neurotransmitter/Neuropeptide:
- Acetylcholine
(Although earlier reports suggested SIB might be glutamatergic, more recent studies showed it is not)
(Serrano-Saiz et al., 2013; Ohnishi et al., 2011;
Loer, 2010; Duerr et al, 2008; Rand and Nonet, 1997-Appendix 2)
Innexin expression:
- INX-9
- INX-12
- UNC-7
- UNC-9
(Altun et al., 2009)
Receptor expression:
Function:
- In wild type animals the NR is positioned around the center of the isthmus of the pharynx. CWN-2, the C. elegans Wnt5 homolog, and SIA and SIB neurons play an essential role in placement of the NR correctly in this position. CWN-2 is required at the time of nerve ring formation and functions through the Wnt receptor CAM-1. CWN-2 is a ligand for CAM-1 (Ror receptor) and CAM-1 expression in SIA and SIB neurons facilitates this function. When this pathway is perturbed the NR is displaced towards the anterior (Kennerdell et al., 2009) |
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