Type: Interneuron
In MoW: LUA
Male Wiring Project:
LUAL,
LUAR
In Wormbase: LUAL, LUAR
Lineage: AB plpppaapap, AB prpppaapap
Location: Left and right lumbar ganglia
Description: Interneuron
Neurotransmitter/ Neuropeptide:
- Glutamate
- NLP-13; neuropeptide-like protein
- PDF-1; pigment dispensing factor homolog
(Pereira et al., 2015; Barrios et al, 2012; Nathoo et al., 2001)
Innexin expression:
- INX-7
- INX-11
- INX-13
(Altun et al., 2009)
Receptor expression:
- GLR-5; glutamate receptor subunit
- SER-2; tyramine receptor (a splice variant)
(Tsalik et al., 2003; Brockie et al., 2001)
Function:
- Suggested to be a "connector cell" between the PLM touch receptors, with which they make gap junctions along the lumbar commissures, and AVA/D interneurons, with which they make chemical synapses in the ventral cord (Chalfie et al., 1985). However, laser ablation does not lead to any abnormalities of movement or touch sensitivity (Chalfie et al., 1985) and no role in tap-withdrawal reflex has been found (Wicks and Rankin, 1995) |
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