Type: Interneuron
Connectivity:
- In MoW: AVE
- In WormWiring: AVEL_h, AVER_h, AVEL_m, AVER_m
- In Nemanode: AVE
In Wormbase: AVE, AVEL, AVER
Lineage: AB alpppaaaa, AB praaaaaaa
Location: Lateral ganglia of head
Description: Ventral cord interneurons. The AVEs send processes into the nerve ring where they receive synaptic input from sensory and interneurons. The processes exit the nerve ring into the ventral cord where they extend to anterior of the vulva. The ventral cord process is predominantly presynaptic with the same synaptic partners as AVD.
Neurotransmitter/ Neuropeptide:
- Acetylcholine
- FLP-1; FMRFamide-like peptide
(Although earlier reports suggested AVE might be glutamatergic, more recent studies showed it is not)
(Pereira et al., 2015; Serrano-Saiz et al., 2013; Ohnishi et al., 2011; Nelson et al., 1998)
Innexin expression:
- INX-1a
- INX-1b
- INX-2
- INX-10a
- INX-14
- INX-19
- UNC-7
- UNC-9
(Bhattacharya et al., 2019)
Receptor expression:
- GLR-1; glutamate receptor subunit
- GLR-2; glutamate receptor subunit
- GLR-5; glutamate receptor subunit
- NMR-1; glutamate receptor subunit
- NMR-2; glutamate receptor subunit
(Maricq et al., 1995; Brockie et al., 2001)
Function: Command interneuron.
- Drives backward movement of the animal along with AVA, AVD and A-type motor neurons. See Locomotory circuit.
Reporters:
- At CGC: NC1750 hdIs32 [glr-1::DsRed2]; gvEx173 [opt-3::GFP + rol-6(su1006)]
- Other: