ADA

ADAL, ADAR

Type: Interneuron
Connectivity:
- In MoW: ADA
- In Wormwiring: ADAL_h, ADAR_h, ADAL_m, ADAR_m
- In Nemanode: ADA
In Wormbase: ADA, ADAL, ADAR
Lineage: AB plapaaaapp, AB prapaaaapp
Location: Cell bodies are located on the lateral sides of the head, at the level of the second bulb of the pharynx.
Description: Integrative ring interneurons. Each ADA neuron process travels within the deirid commissure to enter the retrovesicular ganglion neuropil. This process then travels anteriorly to the nerve ring where it runs dorsally near the center of the ring neuropil. It meets its contralateral partner at the dorsal midline and makes gap junctions with it.
Neurotransmitter/Neuropeptide:
- Glutamate
- Possibly FLP-8, a FMRFamide-like peptide
- PDF-1; pigment dispensing factor homolog
(Loer and Rand, 2022; Janssen et al., 2009; Li and Kim, 2008; Lee et al.,1999)
Innexin expression:
- CHE-7
- INX-1a
- INX-1b
- INX-2
- INX-7
- INX-10a (only in dauer)
- INX-12
- INX-19
- UNC-7
- UNC-9
(Altun et al., 2009; Bhattacharya et al., 2019)
Receptor expression: Unknown
Function: Unknown. However, topological cluster analyses suggest ADA may be involved in chemosensation (Sohn et al., 2011).
Reporters:
- At CGC:
- Others:

Click pictures for higher resolution images

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ADAL (AB plapaaaapp) development in the embryo. Dorsal view. Bottom is left side of the embryo. Spheres indicate individual nuclei. Black sphere: ancestors of ADAL (since last ADAL ancestor has not yet gone through its final division, the black sphere seen at the end of this movie is still AB plapaaaap); dark grey spheres: apoptotic cells; other cells follow the WA color code (after they acquire specific cell or tissue identities). 0 min is fertilization. Click on the movie for higher resolution rendition (by A. Santella & Z. Bao).

Click here for larger version
ADAR (AB prapaaaapp) development in the embryo. Dorsal view. Bottom is left side of the embryo. Spheres indicate individual nuclei. Black sphere: ancestors of ADAR (since last ADAR ancestor has not yet gone through its final division, the black sphere seen at the end of this movie is still AB prapaaaap); dark grey spheres: apoptotic cells; other cells follow the WA color code (after they acquire specific cell or tissue identities). 0 min is fertilization. Click on the movie for higher resolution rendition (by A. Santella & Z. Bao).

Last revision: April 12, 2024