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AMusFIG 6: Body wall muscle cell nuclei in aging C. elegans.
Muscle nuclei visualized with MY0-3::GFP nuclear-localized reporter expressed in body muscle cells. Images of nuclear GFP in bodywall muscle cells from several individual young adults (A), middle-aged 7-day old adults (B) and older 15-day adults (C). In comparison to young adults, where chromatin fills the entire volume except for the nucleolus, the pattern of nuclear GFP in bodywall muscles becomes progressively fragmented and dispersed as animals age. Interestingly, individual nuclei from cells within one animal may develop this nuclear fragmentation at different rates. However, the progression of nuclear GFP fragmentation was correlated with the animal's locomotory class (Herndon et al., 2002).
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