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[Sensory neuron (Mechanosensory)
|OLQsh and OLQso||DESCRIPTION|
Neurons of outer labial quadrant sensilla, ciliated endings with striated rootlets.
Functions: When worms are touched on either the dorsal or ventral sides of their nose with an eyelash, they interrupt the normal pattern of foraging and undergo an aversive head-withdrawal reflex. This simple reflex is mediated by two classes of mechanosensory neurons (OLQ and IL1) and their synaptic targets, the RMD motor neurons. Killing any of these cells, alone or in combination, diminishes the head withdrawal reflex. IL1, OLQ, and RMD also regulate spontaneous foraging movements. Laser operated animals lacking IL1 and OLQ forage abnormally slowly and make exaggerated dorsal and ventral nose turns (Hart A. et al. 1995; Kaplan J. and Driscoll M., 1997).
See head withdrawal and foraging circuit here.
Receptor expression: Express mammalian capsaicin receptor-like channel protein OSM-9 (Colbert H.A. et al 1997). Express osm-9/capsaicin receptor related TRPV protein, OCR-4 (Tobin D. M. et al, 2002). Express neuropeptide Y receptor like protein, NPR-1 (Coates J. C. and de Bono M., 2002).
See osm-9-GFP expression in OLQ cells here (Colbert H. A. et al, 1997).
See eat-20-GFP expression in OLQ cells here (Shibata Y. et al, 2000).
See ocr-4-GFP expression in OLQ cells here (Tobin D. M. et al, 2002).