Table of contents

Studies on the Development and Organisation of the Nervous System of Caenorhabditis elegans
by Richard Michael Durbin

Summary 1987 Preface -- 2001 Preface Download whole document in pdf format (1.6Mb)
Part I - The Outgrowth of Nerve Processes in the Embryo Part II - The Organisation of the Adult Nerve Ring Appendix
Chapter 1: Introduction
  1. A review of neural guidance
  2. The C. elegans nervous system
Chapter 2: Materials and Methods
  1. C. elegans neuronal nomenclature
  2. Electron microscopy
  3. Ablations
  4. Reconstruction
  5. Staging of reconstructed embryos
  6. Identification of neurons
Chapter 3: The Pattern of Outgrowth in Normal Embryos
  1. Morphology of growth cones
  2. The attachment substrate for growth cones
  3. AVG pioneers the ventral cord
  4. Motor neurons
  5. Later ventral cord interneurons
  6. Decussation in the preanal and retrovesicular ganglia
  7. Growth cone insertions into other cells
Chapter 4: Laser Ablation Experiments
  1. AVG
  2. DD3/5
  3. PVP and PVQ
  4. DVC
Chapter 5: Discussion
  1. Reliability
  2. Motor neuron outgrowth and formation of the dorsal cord
  3. Discussion
  4. Selective fasciculation
  5. Conclusion
Chapter 6: Introduction and Methods
  1. Introduction
  2. Methods
Chapter 7: Synaptic Distributions and Reproducibility
  1. Synaptic distributions
  2. Adjacency and synapse formation
  3. Reciprocal synapses and joint chemical/electrical connections
  4. Connections between members of the same neuronal class
  5. Reproducibility of connections
  6. Reproducibility depends on the number of synapses made, not on adjacency
  7. Mismatches of chemical synapses are due to extra connections more often than to missing connections
  8. Connections are not determined purely by neuronal classes
  9. Differences between repeats of equivalent circuitry
  10. Connection formation and adjacency
  11. An underlying pattern of connectivity with additions?
  12. Localisation of synaptic specificity within neurons
  13. Conclusion
Chapter 8: The Logical Organization of the Circuitry
  1. Directionality
  2. The organisation of the feedback
  3. The processing depth
  4. Discussion
Chapter 9: Process Placement in the Nerve Ring
  1. Specific persistent contacts
  2. Identified bundles
  3. Discussion
Appendix 1: The statistical test for synapse number correlation with adjacency
Appendix 2: The sorting algorithm used to order the neural circuitry
Appendix 3: The method used to determine processing depth
Appendix 4: The clustering algorithm used to detect bundles